منابع مشابه
Herbal Compounds and Toxins Modulating TRP Channels
Although the benefits are sometimes obvious, traditional or herbal medicine is regarded with skepticism, because the mechanism through which plant compounds exert their powers are largely elusive. Recent studies have shown however that many of these plant compounds interact with specific ion channels and thereby modulate the sensing mechanism of the human body. Especially members of the Transie...
متن کاملV2A2lidating TRP channel heteromers
Transient receptor potential (TRP) ion channels play a key role in sensing environmental and endogenous stimuli. Among sensory neurons, different TRP channels are widely expressed, and their expression profiles overlap. Although many TRP channels are homotetramers, we have shown that a functional tetrameric TRP channel can contain two types of monomers.
متن کاملTRP channels as drug targets.
Ca2+ channel antagonists acting on electrically-excitable cells have proved to be valuable therapeutic agents. The discovery of such agents and the identification of their molecular target resulted from the investigation of unexpected actions of known pharmacological agents. Ca2+ influx through receptor-operated channels in electrically non-excitable cells such as leukocytes is also functionall...
متن کاملTRP channel proteins and signal transduction.
TRP channel proteins constitute a large and diverse family of proteins that are expressed in many tissues and cell types. This family was designated TRP because of a spontaneously occurring Drosophila mutant lacking TRP that responded to a continuous light with a transient receptor potential (hence TRP). In addition to responses to light, TRPs mediate responses to nerve growth factor, pheromone...
متن کاملMolecular determinants of TRP channel assembly.
Calcium channels play important roles in cellular signalling. TRP (transient receptor potential) channels form a superfamily of calcium channels through which Ca(2+) enters the cell. TRPs have six transmembrane segments with a putative pore between the fifth and the sixth segments, and assemble in tetrameric complexes to form functional Ca(2+) channels. They are thus similar to K(V) (voltage-ga...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2020
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.93.0_2-p-262